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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: The mRNA and protein expression of phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regeneratingliver 3 (PRL-3) in transitional cell carcinoma of bladder (BTCC) and normal epithelia of bladder wasThe expression of PRL-1 and PRL-3 mRNA was detected by using reverse transcription polymerase chain reactionA significantly positive correlation was found between PRL-1 and PRL-3 in BTCC ( <0.05).PRL-1 and PRL-3 are expressed consistently and may contribute to the growth, differentiation, invasion

Keywords： transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regeneratingliver 3     reverse transcription polymerase chain reaction     immunohistochemistry    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract:

Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide.In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressedKaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictorOverexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdownof PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells.

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:

The tumor suppressor gene liver kinase B1 (LKB1), also called STK11, encodes a serine/threonine kinaseLKB1 plays crucial roles in cell differentiation, proliferation, and polarity.In this study, LKB1 conditional knockout mice (LKB1Pax2 CKO mice) were generated usingLKB1Pax2 CKO mice died perinatally.LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity during

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells.

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

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Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellularcarcinoma with liver cirrhosis

CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 287-293 doi: 10.1007/s11684-007-0055-x

Abstract: with liver cirrhosis.Liver function, serum GH, IGF-1 and IGFBP-3 were measured before the operation and at postoperative daysInsulin-like growth factor-1 and IGFBP-3 mRNA in the liver tissue was detected by RT-PCR.The liver Ki67 immunohistochemistry staining was studied.On POD 6, serum prealbumin, GH, IGF-1, IGFBP-3, hepatic IGF-1 mRNA, IGFBP-3 mRNA and liver Ki67 LI were

Keywords： control     function     production     surgical     Complex    

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Measurement of bone alkaline phosphatase and relative study with osteosarcoma

YANG Zhiping, LI Jianmin, LI Xin, HUO Yanqing, SUN Guangzhi

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 54-57 doi: 10.1007/s11684-007-0011-9

Abstract: The objective of this paper is to explore the value of bone alkaline phosphatase (BALP) for diagnosingAlkaline phosphatase (ALP) in blood serum was checked with auto biochemistry equipment.
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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl ).under regular culture, the mice displayed an attenuated response to CCl -induced liver injury.expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2e1)in the liver, especially after CCl treatment for 48 h.These data suggested that the alleviated liver damage induced by CCl in mice was caused by Cyp2e1

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The aim of this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosis-1 (TIMP-1) in different stages of hepatic fibrosis was detected by using RT-PCR.The expression of integrin-β1, TGF-β and TIMP-1 was determined in each group.Liver function and pathological sections of each group in different stages of hepatic fibrosis was testedThe expression of TGF-β and TIMP-1 was consistent with that of integrin-β1 in different stages of hepatic

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 1-7 doi: 10.1007/s11684-010-0105-7

Abstract:

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques becauseSplit liver transplantation provides chances to two or even more recipients when only one liver graftBefore surgery, a series of donor evaluations—including anatomical, liver volume, and liver functionAt different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver

Keywords： partial liver transplantation     reduced-size liver transplantation     split liver transplantation     living donorliver transplantation    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activityof Carboxylesterase 1 and Dipeptidyl Peptidase 4 Article

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Engineering 2022, Volume 19, Issue 12,   Pages 153-165 doi: 10.1016/j.eng.2021.09.014

Abstract: We found that carboxylesterase 1 (CES1), as an intrahepatic marker, and dipeptidyl peptidase 4 (DPP-IVLevels of CES1 and DPP-IV can be used to identify liver damage itself and the inflammatory state, respectivelyWhile the levels of the conventional serological biomarkers alkaline phosphatase (ALP), alanine aminotransferaseOur data highlights the potential of the combined use of CES1 (as an intrahepatic marker of liver damageinjury–an application that allows for the differentiation of liver damage and inflammatory liver

Keywords： Carboxylesterase 1     Dipeptidyl peptidase 4     Liver injury     Validation tracking    

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type 1(AT1R) in hepatic stellate cells (HSCs)The protein expression of AT1R was detected by western blot.( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1RThe expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

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Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 235-238 doi: 10.1007/s11684-008-0044-8

Abstract: is to investigate the effect of tyrosine kinase Src on Tyrosine 307(Y307) phosphorylation, protein phosphatase

Keywords： hyperphosphorylation     PP2A activity     cellular regulation     siRNA     siRNA transfection    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liverfactors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract:

The liver has been characterized as a frontline lymphoid organ with complex immunological featuressuch as liver immunity and liver tolerance.Liver tolerance plays an important role in liver diseases including acute inflammation, chronic infectionThe liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immune

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Title Author Date Type Operation

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article

Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellularcarcinoma with liver cirrhosis

CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming

Journal Article

Measurement of bone alkaline phosphatase and relative study with osteosarcoma

YANG Zhiping, LI Jianmin, LI Xin, HUO Yanqing, SUN Guangzhi

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Partial liver transplantation

Nianqiao GONG, Xiaoping CHEN

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activityof Carboxylesterase 1 and Dipeptidyl Peptidase 4

Qiusha Pan, Peifang Song, Zhenhua Ni, Xingkai Qian, Anqi Wang, Liwei Zou, Yong Liu, Ping Wang, Weidong Zhang, Hong Ma, Ling Yang

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation

LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article